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A6150
Sigma
α1-Antitrypsin from human plasma
salt-free, lyophilized powder
| Synonym: | α1-Proteinase inhibitor |
| CAS Number: | 9041-92-3 |
| EC Number: | 232-924-7 |
| MDL number: | MFCD00130469 |
Description
| Biochem/physiol Actions | Serine protease inhibitor; inhibits trypsin, chymotrypsin and pancreatic and granulocytic elastase, and acrosin. Effective concentration equimolar with proteinase. |
| 5-10 mg will inhibit 1.0 mg of trypsin with activity of 10,000 BAEE units per mg protein. 5-10 mg will inhibit approx. 1.0 mg of α-chymotrypsin with activity of 40-50 BTEE units per mg protein. | |
| Caution | Aqueous stock solutions containing 0.01% NaN3 are stable for several months. Solutions can be stored at −80 °C, but should not be refrozen. Unstable below pH 5.5. Inactivated by some non-serine proteinases and by oxidation of active site methionine residue. |
| Preparation Note | Chromatographically prepared and partially purified. |
Properties
| form | salt-free, lyophilized powder |
| Gene Information | human ... ELA2(1991), SERPINA1(5265) |
| storage temp. | 2-8°C |
Safety
| Hazard Codes | B |
| WGK Germany | 3 |
References
| reference | , Beynon, R.J. and Bond, J.S., ed. Proteolytic Enzymes: A Practical Approach, (1989), 248-249 |
| Pannell, R., et al. Biochemistry 13, 5439, (1974) | |
| Merck | Merck 13,725 |
